Main Outcomes and Measures Odds ratios (ORs), attributable risks, liability R 2 values, and proportions mediated. Results from a separate meta-analysis (34 600 cases and 45 968 control individuals) were applied to calculate polygenic risk scores.Įxposures Polygenic risk scores, parental socioeconomic status, and family psychiatric history. Genome-wide data and family psychiatric and socioeconomic background information were obtained from neonatal biobanks and national registers. The study consisted of 866 patients diagnosed as having schizophrenia between January 1, 1994, and December 31, 2006, and 871 matched control individuals. Objective To estimate (1) how strongly the risk for schizophrenia relates to the mutual effect of the polygenic risk score, parental socioeconomic status, and family history of psychiatric disorders (2) the fraction of cases that could be prevented if no one was exposed to these factors (3) whether family background interacts with an individual’s genetic liability so that specific subgroups are particularly risk prone and (4) to what extent a proband’s genetic makeup mediates the risk associated with familial background.ĭesign, Settings, and Participants We conducted a nested case-control study based on Danish population-based registers. Importance Schizophrenia has a complex etiology influenced both by genetic and nongenetic factors but disentangling these factors is difficult.
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